Index report of cutaneous angiosarcomas with strong positivity for tyrosinase mimicking melanoma with further evaluation of melanocytic markers in a large angiosarcoma series.
Identifieur interne : 000484 ( Main/Exploration ); précédent : 000483; suivant : 000485Index report of cutaneous angiosarcomas with strong positivity for tyrosinase mimicking melanoma with further evaluation of melanocytic markers in a large angiosarcoma series.
Auteurs : Alicia Leon-Castillo [Espagne] ; John S A. Chrisinger [États-Unis] ; Gauri Panse [États-Unis] ; Rashmi T. Samdani [États-Unis] ; Davis R. Ingram [États-Unis] ; Vinod Ravi [États-Unis] ; Victor G. Prieto [États-Unis] ; Wei-Lien Wang [États-Unis] ; Alexander J. Lazar [États-Unis]Source :
- Journal of cutaneous pathology [ 1600-0560 ] ; 2017.
Abstract
Cutaneous angiosarcoma can be challenging to diagnose particularly when poorly vasoformative and studied on biopsies. We report a case of a cutaneous angiosarcoma with strong positivity for tyrosinase, the first to our knowledge, initially misdiagnosed as melanoma. We subsequently evaluated the reactivity of panmelanocytic cocktail (tyrosinase, HMB-45 and Melan-A), SOX10, tyrosinase and MITF in a large tissue microarray (TMA) of angiosarcoma. The TMA included 142 cases of angiosarcomas (29 cutaneous, 22 primary breast, 41 post-radiation breast, 15 visceral, 26 deep soft tissue and bone, 5 chronic lymphedema-associated and 4 angiosarcomas arising in other sarcomas). Immunohistochemical studies were performed with anti-panmelanocytic cocktail, anti-SOX10, anti-MITF and anti-tyrosinase antibodies. TMA staining results were scored on intensity and percentage of tumoral labeling. Aside from the index case, no cases (0 of 133) showed positivity for tyrosinase including 28 cutaneous angiosarcomas. One breast angiosarcoma (1 of 131) was positive for MITF. All cases were negative for SOX10 and panmelanocytic cocktail (0 of 132). Angiosarcomas can rarely be positive for tyrosinase and MITF. Pathologists should be cognizant of these rare exceptions to prevent confusion with melanoma. Additional immunohistochemical markers for vascular and melanocytic differentiation, thorough histological examination for vasoformative and in situ areas as well as clinical impression are helpful in these exceptionally problematic cases.
DOI: 10.1111/cup.12968
PubMed: 28556023
Affiliations:
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Lazar</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston</wicri:cityArea></affiliation></author></analytic><series><title level="j">Journal of cutaneous pathology</title><idno type="eISSN">1600-0560</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cutaneous angiosarcoma can be challenging to diagnose particularly when poorly vasoformative and studied on biopsies. We report a case of a cutaneous angiosarcoma with strong positivity for tyrosinase, the first to our knowledge, initially misdiagnosed as melanoma. We subsequently evaluated the reactivity of panmelanocytic cocktail (tyrosinase, HMB-45 and Melan-A), SOX10, tyrosinase and MITF in a large tissue microarray (TMA) of angiosarcoma. The TMA included 142 cases of angiosarcomas (29 cutaneous, 22 primary breast, 41 post-radiation breast, 15 visceral, 26 deep soft tissue and bone, 5 chronic lymphedema-associated and 4 angiosarcomas arising in other sarcomas). Immunohistochemical studies were performed with anti-panmelanocytic cocktail, anti-SOX10, anti-MITF and anti-tyrosinase antibodies. TMA staining results were scored on intensity and percentage of tumoral labeling. Aside from the index case, no cases (0 of 133) showed positivity for tyrosinase including 28 cutaneous angiosarcomas. One breast angiosarcoma (1 of 131) was positive for MITF. All cases were negative for SOX10 and panmelanocytic cocktail (0 of 132). Angiosarcomas can rarely be positive for tyrosinase and MITF. Pathologists should be cognizant of these rare exceptions to prevent confusion with melanoma. Additional immunohistochemical markers for vascular and melanocytic differentiation, thorough histological examination for vasoformative and in situ areas as well as clinical impression are helpful in these exceptionally problematic cases.</div></front></TEI><affiliations><list><country><li>Espagne</li><li>États-Unis</li></country><region><li>Connecticut</li><li>Texas</li></region></list><tree><country name="Espagne"><noRegion><name sortKey="Leon Castillo, Alicia" sort="Leon Castillo, Alicia" uniqKey="Leon Castillo A" first="Alicia" last="Leon-Castillo">Alicia Leon-Castillo</name></noRegion></country><country name="États-Unis"><region name="Texas"><name sortKey="Chrisinger, John S A" sort="Chrisinger, John S A" uniqKey="Chrisinger J" first="John S A" last="Chrisinger">John S A. Chrisinger</name></region><name sortKey="Ingram, Davis R" sort="Ingram, Davis R" uniqKey="Ingram D" first="Davis R" last="Ingram">Davis R. Ingram</name><name sortKey="Lazar, Alexander J" sort="Lazar, Alexander J" uniqKey="Lazar A" first="Alexander J" last="Lazar">Alexander J. Lazar</name><name sortKey="Panse, Gauri" sort="Panse, Gauri" uniqKey="Panse G" first="Gauri" last="Panse">Gauri Panse</name><name sortKey="Prieto, Victor G" sort="Prieto, Victor G" uniqKey="Prieto V" first="Victor G" last="Prieto">Victor G. Prieto</name><name sortKey="Ravi, Vinod" sort="Ravi, Vinod" uniqKey="Ravi V" first="Vinod" last="Ravi">Vinod Ravi</name><name sortKey="Samdani, Rashmi T" sort="Samdani, Rashmi T" uniqKey="Samdani R" first="Rashmi T" last="Samdani">Rashmi T. Samdani</name><name sortKey="Wang, Wei Lien" sort="Wang, Wei Lien" uniqKey="Wang W" first="Wei-Lien" last="Wang">Wei-Lien Wang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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